50 Cent | All Things Fall Apart | Lost: 54 lbs

American rapper and actor, Curtis James Jackson III, who is professionally known as 50 Cent, lost an astounding 54 pounds during the filming of the 2011 American direct-to-video drama film All Things Fall Apart. In just a span of nine weeks, he was able to lose that much weight, which shows his determination and dedication in portraying his credit role as a football player with cancer in the film. He went from 214 pounds to 160 after undergoing three-hour cardio run on a treadmill and combining it with a liquid diet.

He said in an interview that the challenge of losing weight during this time was tough for him and added that he had to discipline himself to actually have himself be in the physical state to bear the energy he felt. Of course, he was able to gain all the lost weight back and currently weighs just as much as he needs to be.